Promethazine and codeine need to be applied through pregnancy provided that the potential benefit justifies the probable threat to your fetus.
Small children Postmarketing conditions of respiratory depression, like fatalities, are actually documented with utilization of promethazine in pediatric clients. Concomitant administration with other respiratory depressants may improve the chance of respiratory despair.
Prescription drug abuse is the intentional non-therapeutic utilization of a prescription drug, even the moment, for its rewarding psychological or physiological outcomes.
Impaired secretion from sweat glands following toxic doses of medicine with anticholinergic Unwanted side effects may perhaps predispose to hyperthermia.
The respiratory-depressant results of narcotic analgesics as well as their ability to elevate cerebrospinal fluid tension may very well be markedly exaggerated while in the presence of head injury, intracranial lesions or even a pre-present increase in intracranial strain.
Lactation At the least just one Loss of life was documented within a nursing toddler who was exposed to high levels of morphine in breast milk because the mom was an extremely-rapid metabolizer of codeine.
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The phosphate salt of codeine happens as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and a bit soluble in alcohol.
Study the Medication Information supplied by your pharmacist before you start using codeine/promethazine and each time you receive a refill. In case you have any concerns, talk to your medical professional or pharmacist.
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The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced, necessitating cautious consideration of the consequences on the father or mother drug, codeine, plus the Energetic metabolite, morphine.
Cure of Overdose Remedy of overdosage is driven by the general scientific presentation, and consists of discontinuation of Promethazine HCl and Codeine Phosphate Oral Resolution together with establishment of ideal therapy. Give Principal interest for the reestablishment Promethazine codeine syrup of adequate respiratory Trade by means of provision of the patent and protected airway and also the institution of assisted or managed air flow.
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are pregnant or approach to become pregnant. Promethazine Hydrochloride and Codeine Phosphate Oral Solution can damage your unborn child. See “What is A very powerful details I should learn about Promethazine Hydrochloride and Codeine Phosphate Oral Answer?” are breastfeeding or decide to breastfeed. Codeine passes into your breast milk and can result in really serious Negative effects within your child which includes elevated sleepiness, respiratory complications (respiratory melancholy), and Demise. It is far from regarded if promethazine can move into your breast milk.